Performance

Molecular classification based on lung cancer-driven genetic variation can help patients to choose individualized treatment options for precise treatment.

Eight-Gene Mutations Detection Kit (semiconductor sequencing technology) is a clinical diagnostic kit for lung cancer which based on the original one-step patented technology from Genetron Health and approved by NMPA. The eight genes,

EGFR/ALK/ROS1/BRAF/KRAS/HER2/MET/PIK3CA,which related to targeted therapy closely in patients with non-small cell lung cancer can be detected with only 20ng DNA and 50ng RNA at one time. This Kit can detect 50 hotspot variants and 25 fusion gene types.

Principle of Semiconductor Sequencing

Rapid detection: It takes only 1.5 hours to completed the construction of library

Low sample extraction: This kit just need a low sample extraction quantity for DNA and RNA, only 1-3 FFPE slices to meet the requirements, to achieve a higher detection rate and to benefit more patients

Simple and convenient operation: only 15 minutes of manual operation, just one-step PCR process can reduce cross-contamination as much as possible, standardize easily, it is suitable for hospitals to carry out tests independently

Product performance



SampleSensitivityAccuracy
Theformalin fixed paraffin-embedded (FFPE) tumor  tissues of non-small cell lung cancer fixed which should be preserved for no more than 3 years20ng DNA can detect mutations as low as 5%
50ng RNA detects 150 copies of  gene fusion
100% coincidence of negative reference
100% coincidence of positive referenc



Work process
Product Parameters
Application Kit
Supporting instruments and supplies
Gene and Mutations List



NumberGene ListMutations
1

EGFR

19del、L858R、 T790M、G719X、S768I、L861Q 
2KRAS G12V 、G12A 、G12D、G12C、G13D
3BRAFV600E
4PIK3CAE545K、E542K、H1047L、H1047R
5HER220 exon insertion
6ROS1ROS1 fusion
7ALK ALK fusion
8MET Exon 14 skipping


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